F-500 EA is UL listed for use on Class A and Class B fires, although F-500 EA has been used successfully on multiple Class D fires, where other agents have failed. Although not generally used or recommended on Class C fires, F-500 EA has been thoroughly tested on high-voltage lithium-ion battery fires and transformer fires.

Most of the lithium-ion battery fire testing was conducted in Germany by Bosch Group, DEKRA Automobile GmbH, Daimler AG and Deutsche ACCUmotive GmbH & Co. KG and endorsed by the State Fire School Baden-Wurttemberg. They concluded that F-500 EA was the best agent available to extinguish high-voltage battery car fires due to its ability to cool and extinguish the batteries, as well as modern automobile plastic and magnesium components and fuels.